研究業績（論文）

　ここ数年の研究業績を記載します。それ以前や学会発表、獲得資金については各研究室HPにてご確認ください。

2023年

・Uric acid elevation by fructose overload exacerbates NASH and atherosclerosis via oxidative stress, Moe Fujii, Mai Kakimoto, Ikumi Sato,

　Koki Honma, Sora Kirihara, Hinako Nakayama, Taketo Fukuoka, Satoshi Hirohata, Kazuya Kitamori, Shang Ran, Shusei Yamamoto,

　Shogo Watanabe, Current nutrition and food science, in press, 2023.

 

・ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711, Matsuzaki M, Yokoyama M, Yoshizawa

　Y, Kaneko N, Naito H, Kobayashi H, Korenaga A, Sekiya S, Ikemura K, Opoku G, Hirohata S, Iwamoto S, Tanaka K, Tomita T,

　Molecular Psychiatry, published online: 1st February 2023

 

2022年

・Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice, Alcantara MC, Suzuki K,

　Acebedo AR, Kajioka D, Hirohata S, Kaisho T, Hatano Y, Yamagata K, Takahashi S, Yamada G, iScience , Nov 16;25(12):105609.2022 

 

・Suppression of Nitric Oxide Synthase Aggravates Non-alcoholic Steatohepatitis and Atherosclerosis in SHRSP5/Dmcr Rat via

　Acceleration of Abnormal Lipid Metabolism,  Ikumi Sato, Shusei Yamamoto, Mai Kakimoto, Moe Fujii, Koki Honma, Shota Kumazaki,

　Mami Matsui, Hinako Nakayama, Sora Kirihara, Shang Ran, Shinichi Usui, Ryoko Shinohata, Kazuya Kitamori, Satoshi Hirohata,

　Shogo Watanabe, Pharmacological reports, 74 (4), 669-683, 2022

 

・Potential of a novel chemical compound targeting matrix metalloproteinase-13 for early osteoarthritis: an in vitro study. Inagaki J,

　Nakano A, Hatipoglu O.F, Ooka Y, Tani Y, Miki A, Ikemura K, Opoku G, Ando R, Kodama S, Ohtsuki T, Yamaji H, Yamamoto S, Katsuyama E,

　Watanabe S, Hirohata S, Int. J. Mol. Sci. 2022, 23(5): 2681 

 

・Increased Glycine-conjugated and Unconjugated Bile Acid Levels Associated with Aggravation of Nonalcoholic Steatohepatitis and

　Cardiovascular Disease in SHRSP5/Dmcr Rat, Yamamoto S, Sato I, Fujii M, Kakimoto M, Honma K, Akiyama N, Sakai M, Fukuhama N,

　Kumazaki S, Hirohata S, Kitamori K, Yamori Y, Watanabe S. Acta Med Okayama. 2023 Feb;77(1):29-36. 

 

・Basic characteristics between mechanomyogram and muscle force during twitch and tetanic contractions in rat skeletal muscles,

　Ikumi Sato, Shusei Yamamoto, Mai Kakimoto, Moe Fujii, Koki Honma, Shota Kumazaki, Mami Matsui, Hinako Nakayama, Sora Kirihara,

　Shang Ran, Satoshi Hirohata, Shogo Watanabe, Journal of Electromyography and Kinesiology, 62, 102627, 2022.

 

・A high-fat/high-cholesterol diet, but not high-cholesterol alone, increases free cholesterol and apoE-rich HDL serum levels in rats and

　upregulates hepatic ABCA1 expression, Shinohata R, Shibakura M, Arao Y, Watanabe S, Hirohata S, Usui S,

　Biochimie 2022 Jan 24:S0300-9084(22)00021-9.

 

2021年

・Osteopontin Silencing Attenuates Bleomycin-induced Murine Pulmonary Fibrosis by Regulating Epithelial-mesenchymal Transition, 

　Hatipoglu OF, Uctepe E, Opoku G, Wake H, Ikemura K, Ohtsuki T, Inagaki J, Gunduz M, Gunduz E, Watanabe S, Nishinaka T, Takahashi H,

　Hirohata S, Biomedicine & Pharmacother 2021; 139: 111633.

 

・Plasma arginase-1 level is associated with the mental status of outpatients with chronic liver disease, Ogino N, Ikeda F, Namba S,

　Ohkubo S, Nishimura T, Okada H, Hirohata S, Suganuma N, Ogino K, Diagnostics 2021; 11(2): 317. 

 

2020年

・Low plasma apolipoprotein E-rich high-density lipoprotein levels in patients with metabolic syndrome, Shinohata R, Shiga Y, Miura SI,

　Hirohata S, Shibakura M, Ueno-Iio T, Watanabe S, Arao Y, Usui S.  Clin Chim Acta. 2020 Nov;510:531-536. 

 

・Clinical importance of respiratory muscle fatigue in patients with cardiovascular disease, Taya, M., Amiya, E., Hatano, M., Saito, A.,

　Nitta, D., Maki, H., Hosoya, Y., Minatsuki, S., Tsuji, M., Sato, T., Murakami, H., Narita, K., Konishi, Y., Watanabe, S., Yokota, K., Haga, N. &

　Komuro, I., Medicine, 99(34), e21794, 2020.

 

・Efficacy of an Adjunctive Electrophysiological Test-Guided Left Atrial Posterior Wall Isolation in Persistent Atrial Fibrillation Without a

　Left Atrial Low-Voltage Area. Yamaji H, Higashiya S, Murakami T, Hina K, Kawamura H, Murakami M, Kamikawa S, Hirohata S, Kusachi S.

　Circ Arrhythm Electrophysiol. 2020 Aug;13(8):e008191.

 

・Bile acids aggravate nonalcoholic steatohepatitis and cardiovascular disease in SHRSP5/Dmcr rat model, Shusei Yamamoto, Ikumi Sato,

　Natsuki Fukuhama, Natsumi Akiyama, Miku Sakai, Shota Kumazaki, Shang Ran, Satoshi Hirohata, Kazuya Kitamori, Yukio Yamori,

 

　Shogo Watanabe, Experimental and Molecular Pathology, 114,104437, 2020.

 

・Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis.

　Ohtsuki T, Hatipoglu OF, Asano K, Inagaki J, Nishida K, Hirohata S.  Int J Mol Sci. 2020 Apr 29;21(9):3140.

 

・Deficiency of CD44 prevents thoracic aortic dissection in a murine model. Hatipoglu OF, Miyoshi T, Yonezawa T, Kondo M, Amioka N,

　Yoshida M, Akagi S, Nakamura K, Hirohata S, Ito H.  Sci Rep. 2020 Apr 22;10(1):6869. 

 

 ・Yamamoto S, Sato I, Fukuhama N, Akiyama N, Sakai M, Kumazaki S, Ran S, Hirohata S, Kitamori K, Yamori Y, Watanabe S. Bile acids

　aggravate nonalcoholic steatohepatitis and cardiovascular disease in SHRSP5/Dmcr rat model. Exp Mol Pathol. 2020 Apr 1;114:104437.

 

・ポータブル腸電位計と腹部エコーを用いた腸蠕動の 可視化と看護実践のイノベーション、前川 厚子、塩野 雅也、本田 育美、

　吉田 和枝、平野 明美、青山 京子、竹井 留美、渡邊 彰吾、渡辺 修、進藤 勝久、修文大学紀要、12、1-13、2020 

 

2019年

・Activated clotting time on the day of atrial fibrillation ablation for minimally interrupted and uninterrupted direct oral anticoagulation

　therapy: Sequential changes, differences among direct oral anticoagulants, and ablation safety outcomes. Yamaji H, Murakami T, Hina K,

　Higashiya S, Kawamura H, Murakami M, Kamikawa S, Hirohata S, Kusachi S.  J Cardiovasc Electrophysiol. 2019 Dec;30(12):2823-2833.

 

・Bile acid metabolism is an intermediary factor between non-alcoholic steatohepatitis and ischemic heart disease in SHRSP5/Dmcr rats,

　Kumazaki S, Nakamura M, Sasaki A, Tagashira R, Maruyama N, Sato I, Yamamoto S, Ran S, Usui S, Shinohata R, Ohtsuki T, Hirohata S,

　Kitamori K, Mori M, Yamori Y, Watanabe S. Journal of Nutrition and Food Sciences, 9(4): 1-9, 2019. 

 

・Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1. Ohtsuki T,

　Shinaoka A, Kumagishi-Shinaoka K, Asano K, Hatipoglu OF, Inagaki J, Takahashi K, Oohashi T, Nishida K, Naruse K, Hirohata S.

　Exp Cell Res. 2019; 383(2): 111556. 

 

・Effects of Oral Anticoagulants on Patients With Atrial Fibrillation Aged 90 Years and Older: Comparison Among Direct Oral Anticoagulant,

　Warfarin Anticoagulant, and Nonanticoagulation. Yamaji, H., Higashiya, S., Murakami, T., Hina, K., Kawamura, H., Murakami, M.,

　Kamikawa, S., Hirohata, S. & Kusachi, S.   J Cardiovasc Pharmacol. 2019 Sep;74(3):246-254. 

 

・Serum malondialdehyde-modified low-density lipoprotein levels on admission predict prognosis in patients with acute coronary syndrome

　undergoing percutaneous coronary intervention. Amioka N , Miyoshi T , Otsuka H , Yamada D , Takaishi A , Ueeda M , Hirohata S , Ito H.

　J Cardiol. 2019; 74(3): 258-266.

 

・Adjunctive left anterior line ablation induced left atrial dysfunction and dyssynchrony in atrial fibrillation ablation. Heart Vessels.   

　Yamaji H, Murakami T, Hina K, Higashiya S, Kawamura H, Murakami M, Kamikawa S, Hirohata S, Kusachi S. 2019 Feb; 34(2): 331-342. 

 

2018年

・Non-alcoholic steatohepatitis aggravates nitric oxide synthase inhibition-induced arteriosclerosis in SHRSP5/Dmcr rat model.

　WatanabeS, Kumazaki S, Yamamoto S, Sato I, Kitamori K, Mori M, Yamori Y, Hirohata S.  Int J Exp Pathol 2018; 99(6): 282-294.

 

・High molecular weight hyaluronan protects cartilage from degradation by inhibiting aggrecanase expression. Ohtsuki T, Asano K,

　Inagaki J, Shinaoka A, Kumagishi-Shinaoka K, Cilek MZ, Hatipoglu OF, Oohashi T, Nishida K, Komatsubara I, Hirohata S. J Orthop Res.

　2018 Dec; 36(12): 3247-3255. 

 

・Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth. Asano K, Edamatsu M, Hatipoglu OF, Inagaki J, Ono M, Ohtsuki T, Oohashi T,

　Hirohata S. Acta Med Okayama. 2018 Jun;72(3):257-266.

 

・Differences in activated clotting time and initial heparin dosage during atrial fibrillation ablation for patients with edoxaban compared

　with warfarin. Yamaji H, Murakami T, Hina K, Higashiya S, Kawamura H, Murakami M, Kamikawa S, Hirohata S, Kusachi S. J Cardiovasc

　Electrophysiol. 2018 Jun;29(6):835-843.

 

・A High-Fat and High-Cholesterol Diet Induces Cardiac Fibrosis, Vascular Endothelial, and Left Ventricular Diastolic Dysfunction in

　SHRSP5/Dmcr Rats. Watanabe S, Kumazaki S, Kusunoki K, Inoue T, Maeda Y, Usui S, Shinohata R, Ohtsuki T, Hirohata S, Kusachi S,

　Kitamori K, Mori M, Yamori Y, Oka H.  J Atheroscler Thromb. 2018 May 1; 25(5): 439-453.